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KMID : 0043320040270111081
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Archives of Pharmacal Research
2004 Volume.27 No. 11 p.1081 ~ p.1085
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Synthesis and Study of Antibacterial and Antifungal Activities of Novel 2-[[(Benzoxazole/benzimidazole-2-yl)sulfanyl]acetylamino]thiazoles
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Kaplancikli Zafer-Asim
Gulhan Turan-Zitouni
Revial Gilbert
Guven Kiymet
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Abstract
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Several 2-[[(benzoxazole/benzimidazole-2-yl)sulfanyl]acetylamino]thiazoles derivatives were synthesized by reacting 4-substituted-2-(chloroacetylamino)thiazoles with benzoxazole/benzimidazole-2-thioles in acetone and in the presence of . The chemical structures of the compounds were elucidated by IR, , and spectral data. Their antimicrobial activities against Micrococcus luteus (NRLL B-4375), Bacillus cereus (NRRL B-3711), Proteus vulgaris (NRRL B-123), Salmonella typhimurium (NRRL B-4420), Staphylococcus aureus (NRRL B-767), Escherichia coli (NRRL B-3704), Candida albicans and Candida globrata (isolates obtained from Osmangazi Uni. Fac.of Medicine) were investigated and in this investigation, a significant level of activity was illustrated.
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KEYWORD
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Thiazole, Benzoxazole, Benzimidazole, Antimicrobial activity
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